Throughout history, cannabis alleviated a variety of health issues. However, it wasn’t until the 1960s did researchers begin to investigate why cannabis worked. In 1964, a scientist named Raphael Mechoulam isolated CBD and THC for the first time. The results from this study changed everything we know about cannabis and hemp today – the discovery of the endocannabinoid system (ECS).

What is the Endocannabinoid System? (ECS)

The ECS is a biological system present in all humans and most animals. Its primary role is to maintain physical stability. The ECS contains CB1 and CB2 cell receptors found throughout the body. Chemical messengers such as cannabinoids bind to those receptors.

CB1 receptors are located mainly within the brain and spinal cord, while CB2 receptors are found in the nervous system. THC is shown to activate these receptors while CBD does not. Instead, it indirectly influences the signaling between the two. Above all, it interacts with non-cannabinoid receptors like adenosine, serotonin, and vanilloid receptors.

So, why is this significant? Basically, these interactions help explain why CBD works for alleviating a variety of health conditions. For example, we know that high concentrations of Cannabidiol activate the 5-HT1A serotonin receptor. Activating this receptor is shown to influence anxiety, sleep, appetite, pain perception, and depression.

Therapeutic Potential of CBD

Cannabidiol’s full therapeutic and health impact is developing even more. We have only scratched the surface. However, the information we do have is telling. It is clear that the ECS plays a vital role in almost every bodily system, therefore, by consuming cannabinoids from hemp, we supplement and support this system. Here are just a few of the many potential therapeutic uses of Cannabidiol:

Sleep Apnea/Insomnia


Freshleaf CBD is a holistic approach to medicine.

We are not doctors and do not claim Cannabidiol (CBD) can diagnose, cure, or treat any disease. We do believe, however, CBD offers life-enhancing benefits and relief for some ailments. What’s more is that our products contain 99.9% pure cannabidiol (CBD) isolate derived from domestically grown USA hemp.

Consuming Freshleaf CBD products will never produce psychoactive effects.

We recommend starting with a low dose and gradually working your way up as necessary.


The FDA does not evaluate these statements. They are not intended to diagnose, treat or cure any disease. Always check with your physician before starting a new dietary supplement program